Tubulointerstitial Nephritis and Uveitis Syndrome Associated With Human Papillomavirus Vaccine.

tient was examined by an ophthalmologist and diagnosed as having mild bilateral non-granulomatous anterior uveitis. The diagnosis of TINU syndrome was made. Oral and topical corticosteroid therapy relieved her symptoms. Her renal function has remained stable for 3 years, although topical corticosteroid is necessary for her uveitis. Patient 2 was a 14-year-old girl who presented with painful bloodshot eyes and photophobia 10 weeks after the third dose of HPV vaccination. She was anorexic with a 6-kg weight loss in 10 weeks. She was not taking any medications. Laboratory findings revealed slightly elevated serum creatinine (0.78 mg/dL), glycosuria, proteinuria with increased levels of low molecular weight proteinuria, and hematuria (Table 1). Tests for anti-SSA and anti-SSB antibodies were negative. Abdominal ultrasonography revealed mild bilateral renal swelling with hyperdense areas. Significant renal uptake was demonstrated on 67Ga-citrate scintigraphy. The patient was examined by an ophthalmologist and diagnosed as having mild bilateral non-granulomatous anterior uveitis. The diagnosis of TINU syndrome was made. Oral (1 mg/kg/day) and topical corticosteroid therapy alleviated all symptoms. Tubulointerstitial Nephritis and Uveitis Syndrome Associated With Human Papillomavirus Vaccine